We are interested in the mechanisms leading to Alzheimer's disease, with a special emphasis on the role of APOE and glial cells.
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Led by Dr. Alberto Serrano-Pozo, we are an interdisciplinary team dedicated to ensuring a brighter future for patients with neurodegenerative diseases.
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We are located in Charlestown, MA within the MassGeneral Institute for Neurodegenerative Disease (MIND) at Massachusetts General Hospital and Harvard Medical School.
Learn morePlease see some of the most recent publications and projects from our group below.
Published in Alzheimer's & Dementia, this study uses laser capture microdissection and RNA-seq to reveal distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease.
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Published in Acta Neuropathologica, this work characterizes monoamine oxidase-B as a biomarker of reactive astrogliosis in Alzheimer's disease, supporting PET imaging development.
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Published in Nature Neuroscience, this single-nucleus RNA sequencing study maps astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease across 628,943 astrocytes.
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This review, published in Nature Reviews Neurology, summarizes the multifaceted roles of APOE in Alzheimer disease and highlights progress toward APOE-directed therapeutics.
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A public database of astrocyte immunohistochemical studies in postmortem Alzheimer's disease brains.
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Recently published in Nature Neuroscience, this consensus statement advocates for increased nuance in reactive astrocyte classification.
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This review, published in The Lancet Neurology, charts the progress in the effort to design APOE-based therapies for Alzheimer's disease.
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Published in the Journal of Neuroinflammation, this meta-analysis of mouse transcriptomics indicates that astrocyte reaction is context-dependent.
Learn moreInterested in our work? Please don't hesitate to reach out. We look forward to hearing from you.
